BIOCHEMICAL CHANGES IN THE EVOLUTION OF CHRONIC KIDNEY DISEASE ASSOCIATED WITH URINARY TRACT INFECTIONS

The interrelationship of pathogenicity between urinary tract infections and chronic kidney disease is an incompletely debated issue. In chronic kidney disease, a variety of quite different substances (uremic toxins, betaine, amino acids, creatinine, urea, glucose) influence the microbial environment by biochemical changes. The study was performed in one year period on a group of 105 patients admitted in a Nephrology Department, with urinary tract infection in the presence or absence of CKD. In the group with UTI and CKD, predominated females in the postmenopausal period, especially in CKD stages with higher severity. Analyzing the recurrent UTIs and deaths we have found the presence of advanced age, female gender, pre-existing kidney disease, diabetes mellitus, hemodialysis and a large number of multi-resistant urinary microbial strains. The use of mathematical relationships allowed us to make some correlations between CKD evolution with or without UTI. However, having a small group of patients over one year period with less few subgroups of demographic, causal, comorbidity and biological factors, risk factors for reinfection or death has sometimes made it impossible to interpret mathematically the data obtained from the retrospective observational study.