Inhibition of Taq polymerase activity by singlet oxygen generation at photodynamic therapy
Journal of Physics Conference Series(2018)
摘要
The goal of this study was to assess the ability of singlet oxygen generated at PDT to inhibit the activity of the model enzyme- Taq polymerase. Experimentally were determined the laser irradiation dose and the singlet oxygen concentration (over 300 M) that results to complete inhibition of Taq polymerase activity. The results show that enzymatic proteins have an order of magnitude higher susceptibility than DNA molecules to damage by singlet oxygen.
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关键词
photodynamic therapy,taq polymerase activity,singlet oxygen generation
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