Identification of the Interferon-Inducible GTPase GBP1 As a Major Restriction Factor for Hepatitis E Virus

Although HEV represents a worldwide public health problem with 20 million infections and 44,000 deaths per year, there are still no specific antivirals available and many aspects of the viral life cycle are not well understood. Here, we identify guanylate binding protein 1 (GBP1) as a restriction factor affecting the life cycle of HEV.