Low Sodium To Potassium Ratio In Spot Urine Sample Is Associated With Progression To Acute Kidney Injury And Mortality In Hospitalized Patients With Cirrhosis

Background: sodium to potassium ratio in spot urine sample (Na/K-ur) is a surrogate marker of sodium excretion that is recommended for the management of patients with ascites due to cirrhosis.Aims: to investigate Na/K-ur ratio and fractional excretion of sodium (FENa) in patients admitted with decompensated cirrhosis, evaluating its relationship with acute kidney injury (AKI) and prognosis.Methods: prospective cohort study included 225 adult subjects. Urine samples were obtained within 48 h of hospitalization.Results: AKI at admission was observed in 32.9% of patients and was associated with lower Na/K-ur ratio, but not FENa. Among 151 subjects initially without kidney dysfunction, AKI at some point during hospitalization occurred in 26.2% and was independently associated with low Na/K-ur ratio at admission. AKI was observed in 44% of the patients with Na/K-ur ratio 1 and only in 8% when values 1 and 93.6% for values 1.Conclusions: low Na/K-ur ratio in spot urine sample is associated with progression to AKI and lower shortterm survival in patients hospitalized for decompensated cirrhosis. (C) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.