Purification, Characterization, And Antiproliferative Activity Of A Single-Chain Lectin From Vicia Palaestina (Fabaceae) Seeds
CHEMISTRY & BIODIVERSITY(2021)
摘要
Vicia palaestina Boiss. is an annual herb that grows in dry areas of eastern Mediterranean countries. It belongs to section Cracca subgenus Vicilla, which is characterized by having a high content in the non-protein amino acid canavanine. The seeds from some of these vetches are also rich in lectins. The purification and characterization of a single-chain lectin from the seeds of V. palaestina is described here. This lectin was the most abundant protein in albumin extracts. It has affinity for the glycoconjugate N-acetylgalactosamine and inhibits proliferation of the cancerous Caco-2 and THP-1 cell lines. In addition to their high nutritional value, the seeds from V. palaestina represent a source of lectins with health promoting and pharmacological potential because of their antiproliferative activity.
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关键词
seed lectin, V, palaestina, N-acetylgalactosamine, antiproliferative activity
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