Novel Benzosuberone-quinazolinone Derivatives: Synthesis and Antitumour Activity

Novel benzosuberone-quinazolinones hybrids have been synthesized efficientlyin high yields, and their structures have been confirmed by1H and 13C NMR,ESI-MS, and HRMS spectra. According to the in vitro tests of products for theirantiproliferative activity against HeLa, MDA-MB-231, A549, and MIAPACA cancercell lines, the compound 9b demonstratessignificant cytotoxicity against A549 with GI50 value 0.4µM and compound 8a exhibits activity againstMIAPACA with GI50 value 0.6 µM.