Abstract 15818: Three-dimensional Electroanatomic Mapping of Human Ventricular Tachycardia

Introduction: The localization of sources responsible for erratic ventricular tachycardia signaling can be facilitated by high-resolution epicardial mapping. Here, we describe an approach for epicardial mapping using 3D printed electrode mapping arrays. We utilize these mapping arrays to perform global beat-to-beat epicardial mapping of ex vivo Langendorff perfused human hearts and demonstrate the ability to identify sources of ventricular tachycardia. Hypothesis: The identification of ventricular tachycardia sources can be facilitated by epicardial mapping with 3D printed flexible mapping arrays. Methods: Epicardial shells were printed using a stereolithography 3D printer using flexible photopolymer resin followed by coupling with custom-designed flexible electrode arrays. Global electroanatomic maps were obtained from Langendorff perfused human hearts during sinus rhythm and after extra stimulus pacing induced ventricular tachycardia. Results: We demonstrate the use of 3D-printed electrode mapping arrays to perform global electroanatomic mapping of the human ventricular epicardium. Flexible 3D printed electrode arrays facilitate high spatial-temporal capture of electrophysiological data in Langendorff perfused human hearts and are capable of identifying epicardial sites of ventricular tachycardia. Conclusions: We report on flexible electrode mapping arrays shaped to match the epicardial contours of the human left and right ventricle. We demonstrate the ability to perform high spatiotemporal resolution mapping of human epicardial signals and demonstrate beat-to-beat global capture of ventricular tachycardia.