Metabolic Changes in Hypothalamic Glial Cells under Pathological Conditions of Cancer Cachexia

Cancer cachexia affects many patients with terminal cancer. It significantly reduces their quality of life and also affects their survival rate. Biological homeostasis helps the body adapt to stimuli such as stress and environmental changes, and a breakdown of this control mechanism is thought to lead to the development of various diseases. To better understand the fluctuations of biological homeostasis in these disease pathologies, it is important to understand cellular metabolomics. In this study, we focused on metabolic changes in hypothalamic glial cells under conditions of cancer cachexia. As a result, we found that the expression of several mRNAs involved in glycolysis and the TCA cycle were markedly altered in glial cells isolated from the hypothalamic region of cancer cachexia model mice. Based on these results, we speculate that metabolic abnormalities may be induced in hypothalamic glial cells under the pathological condition of cancer cachexia. We are currently investigating the details by a comprehensive metabolomic analysis.