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Nattokinase mitigated dextran sulfate sodium-induced chronic colitis by regulating microbiota and suppressing tryptophan metabolism via inhibiting IDO-1

Lvqi Zhou,Ning Hao,Xiaotian Li,Jiaxi Chen,Runyu Yang,Changqin Song,Yang Sun,Qi Zhang

Journal of Functional Foods（2020）

Cited 7|Views5
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Abstract
•NK relieved DSS-induced chronic colitis.•NK maintained mucosal integrity by inhibiting apoptosis.•NK regulated gut microbiota of DSS-induced chronic colitis.•NK suppressed Trp metabolism via inhibiting IDO-1 in DSS-induced chronic colitis.
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Key words
Nattokinase (NK),Chronic colitis,Gut microbiota,Tryptophan metabolism,Indoleamine 2,3-dioxygenase 1 (IDO-1)
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