Screen-Detected Breast Cancers Have Different Tumor Biology And Better Prognosis Compared To Interval Breast Cancers

Background: Studies have shown that screen-detection by national screening programs is independently associated with better prognosis of breast cancer. This association can not only be explained by clinical-pathological prognostic factors. Previously, we showed there was a significantly higher proportion of breast cancers with a high risk tumor biology according to the 70-gene signature (70-GS) among interval cancers compared to screen-detected cancers. The aim of this study is to evaluate the association between tumor biology and survival for screen-detected and interval breast cancers.