Brit-1 Expression And Its Relationship With Parp-1 And Caf-1/P60 In Cutaneous Melanoma

Daniela Russo,Antonio Travaglino,Silvia Varricchio,Francesco Merolla,Gennaro Ilardi,Antonio Raffone,Massimiliano Scalvenzi,Claudia Costa,Gabriella Fabbrocini,Stefania Staibano,Massimo Mascolo

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY（2021）

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摘要

Defect of BRCA1 C terminus-repeat inhibitor of human telomerase expression-1 (BRIT-1), a protein involved in DNA repair, appears to promote growth and aggressiveness of several human cancers [1]. Mutations in the nuclear localization signals within the BRIT-1-encoding gene have been described, which may lead to an aberrant cytoplasmic localization of the protein [1].

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关键词

BRCT-repeat inhibitor of hTERT expression (BRIT1),Chromatin Assembly Factor-1 (CAF-1),Melanoma,Poly (ADP-ribose) polymerases 1 (PARP1),microcephalin 1 (MCPH1)

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