Abstract A087: Community Research Navigators (CRN): the Bridge to Increasing Latino Participation in Clinical Research

Abstract The participation of underserved ethnic minorities in biomedical research is critical to achieving progress in health equity. Increasing ethnic minority including Latino accrual in biomedical research, including clinical trials, is a formidable challenge that requires improving participant trust and commitment and overcoming of barriers to participation. Latinos make up about 18% of the US population. Yet Latinos are not adequately targeted in research studies, currently constituting only 7.6% of NIH clinical trial participants and only about 2%-5% of participants in cancer clinical trials. The National Cancer Institute (NCI) has recommended patient navigation as a research strategy that may be adapted to overcome ethnic minority biomedical research and clinical trial participation barriers. City of Hope has participated in training community research navigators (CRN) to increase diversity participation. These CRNs are trained to address gaps in knowledge, medical mistrust, access to participation, and engagement of under-represented groups in biomedical research. The research navigator draws from the patient navigation and promotora model and the community-engaged research approach. CRNs' curriculum include the importance of biomedical to disease prevention, diagnosis, and treatment; the value to group and family participation, Clinical Trials, HIPPA, human subject protection, ethics; patient-provider communication, cost and coverage, and family communication and decision making. In total, we trained and mentored a team of 30 CRNs from our community partner Pomona's Health Promoters for increased public education and Latino participation in research. CRNs were 25-74 years old, 97% female, 96% foreign-born, and 54% < high school education. Their pre- and post-test results showed an increase in willingness to participate in research (p < .005); increase in knowledge of the importance of biomedical including clinical research (p < .000); and an increase in confidence in improving community's attitude and knowledge about clinical research (p < .000). Our findings suggest that the CRN training is effective in improving appropriate knowledge and confidence to conduct community research navigation. This approach holds the promise of utility and applicability to address barriers to research enrollment and increase Latino biomedical research participation. Citation Format: Mayra Serrano, Marisela Garcia, Rick Kittles, Kimlin Tam Ashing. Community Research Navigators (CRN): The bridge to increasing Latino participation in clinical research [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A087.