Exploring Inclusion Complexes of Cyclodextrins with Quinolinone Based Gastro Protective Drug for Enhancing Bioavailability and Sustained Dischargement

Solid rebamipide based inclusion complexes were achieved by freezedry method and characterized by FTIR, UV-visible, H-1-NMR, 2D-ROESY, fluorescence spectroscopy, SEM and conductance. The enzyme substituted emission spectrum of the two comparative inclusion complexes with beta-cyclodextrin (beta-CD) and HP-beta-CD in the diverse solvent systems determined the controlled release of the drug were the mid of interest. Amylase increased the stability of the inclusion complexation, proved that if it is taken together with the inclusion complex, the effectiveness and impact of the inclusion complexes will have a prolonged effect in the body. It could significantly improve the bioavailability of rebamipide.