Iso-octenidine: Promising Octenidine Analogue with Improved Solubility.

Igor K. Yakuschenko, Nataliya N. Pozdeeva,Viktoriya A. Mumyatova,Alexey A. Terentiev,Svyatoslav Ya Gadomsky

Current organic synthesis（2021）

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摘要

Iso-octenidine, an isomer of octenidine dihydrochloride, was synthesized and studied for the first time. Iso-octenidine was demonstrated to be 3-fold more soluble in water in comparison to original octenidine, and both substances had remarkably similar antibacterial activity (tested on Escherichia Coli and Micrococcus luteus).

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关键词

Octenidine dihydrochloride,bispyridinium salts,alkylation reaction,organic synthesis,solubility,antibacterial activity

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