Effect of Codeine on Urine Metabolism in Rats

Codeine, a commonly used cough drug, belongs to opioids, which is used more by drug abusers as an addictive substance. Except tablets, some other preparations of codeine are relatively easy to obtain, and at present in the youth codeine addicts have reached a large number due to cough drug abuse. In order to further comprehend the mechanism of codeine, the effects of codeine on the metabolic pathway of rats were studied by searching the relative relationship between metabolites (urine) and physiological and pathological changes. The metabolites were analyzed by gas chromatography-mass spectrometer, the data were processed by principal component analysis (PCA) and PLS-DA by SIMCA-P 13.0 software, and statistical analysis by SPSS18.0 software. The results indicated that codeine induced metabolic disorder, and Metabolomics could provide a useful tool for the metabolic changes of rats.