Measuring the Biomechanical Properties of Prostate Tumor Tissues by Atomic Force Microscopy

Tumor progression and metastasis are often accompanied by the changes in the biomechanical properties of tumor tissues. In this study, the relationship between the pathological classification of different prostate tumor tissues and their biomechanical properties was investigated by atomic force microscopy. The results showed that higher pathological grade of prostate tumor tissues had lower elasticity and viscosity. Compared with traditional pathological analysis, the biomechanical characteristics of tumor tissues obtained by atomic force microscopy could offer a new index for fast clinic diagnosis and differentiation of tumor tissue. It can be used to assist in the assessment of Gleason scores of the gold standard for prostate cancer grading for radical prostatectomy.