Accelerated human epidermal turnover driven by increased hyaluronan production

Yoko Endo,Hiroyuki Yoshida,Yukiko Ota,Yumiko Akazawa,Tetsuya Sayo,Ushio Hanai,Kotaro Imagawa,Masashi Sasaki,Yoshito Takahashi

Journal of Dermatological Science（2021）

Cited 7|Views25

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Abstract

•Hyaluronan (HA) is an essential component of extracellular matrix in the skin.•1-ethyl-β-N-acetylglucosaminide (β-NAG2) is a selective inducer of HA production.•β-NAG2 increased epidermal HA and thickness in reconstructed human skin equivalents.•Epidermal proliferation and differentiation were promoted via enhanced HA production.•Epidermal HA production plays a key role in epidermal morphogenesis and homeostasis.

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Key words

BPE,dsDNA,ELISA,EGF,FLG,GlcUA,H&E,HA,HABP,HAS,KGF,NAG,β-NAG2,PBS,PCNA,PUGNAc,RPLP0,siRNA,TGM1,UDP

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