Clinical serum metabolomics study on fluoxetine hydrochloride for depression

Dandan Shen,Huan Zhao,Shan Gao,Yue Li,Qi Cheng,Chenghao Bi,Zhihuan Zhou,Yubo Li,Chunquan Yu

Neuroscience Letters（2021）

引用 5|浏览14

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摘要

•Evaluation of fluoxetine hydrochloride treatment effect from metabolomic perspective.•Pathogenesis of depression may be related to amino acid metabolism, energy metabolism and lipid metabolism.•Amino acid metabolism affects the pathogenesis of depression by synthesizing neurotransmitters in the brain.

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UPLC-Q-TOF/MS,CNS,WHO,SSRI,SNRI,5-HT,HAMD,CUMS,DSM-IV,HAMA,NE,DA,PCA,PLS-DA,VIP,AUC,Met-PA,TCA cycle,5-HIAL,DHEA,TXB2,TXA2

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