Optimization on Preparation of Ethanolamine Hydroxyl Platinum (IV) by Response Surface Methodology

Some preparation parameters of ethanolamine hydroxyl platinum(IV), including concentration of platinum, the amount of oxidant and sodium hydroxide, were tested by single factors experiment design, and optimized by a response surface method. Then an empirical mathematical model was established to predict yield of ethanolamine hydroxyl platinum(IV). The results demonstrate that the significance of influence factors is in the order of platinum concentration>NaOH amount>oxidant amount. The yield of ethanolamine hydroxyl platinum(IV) is 89. 26% when the optimized conditions are platinum concentration 100 g.L-1, oxidant amount 10%, and NaOH amount 2.25 times (in mass). The empirical mathematical model is feasible for the optimized parameters to prepare ethanolamine hydroxyl platinum(IV) and to predict its yield. The structural formula of the compounds is verified to be (NH3CH2CH2OH)(2)Pt(OH)(6) by the sample characterization.