Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

Elena Ferri,Adrien Le Thomas,Heidi Ackerly Wallweber,Eric S. Day,Benjamin T. Walters,Susan E. Kaufman,Marie-Gabrielle Braun,Kevin R. Clark,Maureen H. Beresini,Kyle Mortara, Yung-Chia A. Chen, Breanna Canter,Wilson Phung,Peter S. Liu,Alfred Lammens,Avi Ashkenazi,Joachim Rudolph,Weiru Wang

NATURE COMMUNICATIONS（2020）

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关键词

Endoplasmic reticulum,Kinases,Small molecules,Stress signalling,X-ray crystallography,Science,Humanities and Social Sciences,multidisciplinary

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