How Are HBV-specific CD8+ T-cell Responses Induced?

Masanori Isogawa,Yasuhiro Murata,Keigo Kawashima,Yasuhito Tanaka

Future Virology（2018）SCI 4区

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Future VirologyVol. 13, No. 12 EditorialHow are HBV-specific CD8+ T-cell responses induced?Masanori Isogawa, Yasuhiro Murata, Keigo Kawashima & Yasuhito TanakaMasanori Isogawa*Author for correspondence: Tel.: +81 52 853 8191; Fax: +81 52 842 0021; E-mail Address: misogawa@med.nagoya-cu.ac.jp Department of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan, Yasuhiro Murata Department of Hepatobiliary Pancreatic & Transplant Surgery, Mie University Graduate School of Medicine, 2–174 Edobashi, Tsu, Mie 514-8507, Japan, Keigo Kawashima Department of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan Department of Gastroenterology & Hepatology, Yokohama City University School of Medicine, 3–9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan & Yasuhito Tanaka Department of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Nagoya 467-8601, JapanPublished Online:22 Nov 2018https://doi.org/10.2217/fvl-2018-0164AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: antigen presentationCD8+ T cellcross-presentationhepatitis B virusliverprimingReferences1 Isogawa M, Tanaka Y. Immunobiology of hepatitis B virus infection. Hepatol. Res. 45(2), 179–189 (2014).Crossref, Medline, Google Scholar2 Thimme R, Wieland S, Steiger C et al. CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J. Virol. 77(1), 68–76 (2003).Crossref, Medline, CAS, Google Scholar3 Isogawa M, Chung J, Murata Y, Kakimi K, Chisari FV. CD40 activation rescues antiviral CD8+ T cells from PD-1-mediated exhaustion. PLoS Pathogens 9(7), e1003490 (2013).Crossref, Medline, CAS, Google Scholar4 Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu. Rev. Immunol. 25(1), 171–192 (2007).Crossref, Medline, CAS, Google Scholar5 Haan den JM, Bevan MJ. Antigen presentation to CD8+ T cells: cross-priming in infectious diseases. Curr. Opin. Immunol. 13(4), 437–441 (2001).Crossref, Medline, Google Scholar6 Murata Y, Kawashima K, Sheikh K, Tanaka Y, Isogawa M. Intrahepatic cross-presentation and hepatocellular antigen presentation play distinct roles in the induction of HBV-specific CD8+ T cell responses. J. Virol. 92(21), pii:e00920-18 (2018).Crossref, Google Scholar7 Hochweller K, Striegler J, Hämmerling GJ, Garbi N. A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur. J. Immunol. 38(10), 2776–2783 (2008).Crossref, Medline, CAS, Google Scholar8 Bowen DG, Zen M, Holz L, Davis T, McCaughan GW, Bertolino P. The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. J. Clin. Invest. 114(5), 701–712 (2004).Crossref, Medline, CAS, Google Scholar9 Holz LE, Benseler V, Bowen DG et al. Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death. Gastroenterology 135(3), 989–997 (2008).Crossref, Medline, Google Scholar10 Schirmbeck R, Melber K, Reimann J. Hepatitis B virus small surface antigen particles are processed in a novel endosomal pathway for major histocompatibility complex class I-restricted epitope presentation. Eur. J. Immunol. 25(4), 1063–1070 (1995).Crossref, Medline, CAS, Google Scholar11 Bohm W, Schirmbeck R, Elbe A et al. Exogenous hepatitis B surface antigen particles processed by dendritic cells or macrophages prime murine MHC class I-restricted cytotoxic T lymphocytes in vivo. J. Immunol. 155(7), 3313–3321 (1995).Medline, CAS, Google Scholar12 Zinkernagel RM. On cross-priming of MHC class I-specific CTL: rule or exception? Eur. J. Immunol. 32(9), 2385–2392 (2002).Crossref, Medline, CAS, Google Scholar13 Freigang S, Egger D, Bienz K, Hengartner H, Zinkernagel RM. Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming. Proc. Natl Acad. Sci. USA 100(23), 13477–13482 (2003).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByEarly events in hepatitis B infection: the role of inoculum dose10 February 2021 | Proceedings of the Royal Society B: Biological Sciences, Vol. 288, No. 1944 Vol. 13, No. 12 Follow us on social media for the latest updates Metrics Downloaded 32 times History Received 27 September 2018 Accepted 23 October 2018 Published online 22 November 2018 Published in print December 2018 Information© 2018 Future Medicine LtdKeywordsantigen presentationCD8+ T cellcross-presentationhepatitis B virusliverprimingAcknowledgmentsThe authors thank Francis V Chisari (The Scripps Research Institute) for continuous guidance and encouragement.Financial & competing interests disclosureThis study was partially supported by a grant R01AI79060 from the National Institutes of Health (M Isogawa), grants-in-aid from the Ministry of Education, Cultures, Sports, Science, and Technology, Japan, and from Japan Society for the Promotion of Science (M Isogawa), the GSK Japan Research Grant 2017 (K Kawashima), the Gilead Japan Research Grant 2017 (M Isogawa) and the Research Program on Hepatitis from the Japan Agency for Medical Research and Development (M Isogawa and Y Tanaka). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download

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antigen presentation,CD8(+) T cell,cross-presentation,hepatitis B virus,liver,priming

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