Proteomics For Autophagy Receptor And Cargo Identification In Plants
JOURNAL OF PROTEOME RESEARCH(2021)
摘要
Autophagy is a catabolic process facilitating the degradation of cytoplasmic proteins and organelles in a lysosome or vacuole-dependent manner in plants, animals, and fungi. Proteomic studies have demonstrated that autophagy controls and shapes the proteome and has identified both receptor and cargo proteins inside autophagosomes. In a smaller selection of studies, proteomics has been used for the analysis of post-translational modifications that target proteins for elimination and protein-protein interactions between receptors and cargo, providing a better understanding of the complex regulatory processes controlling autophagy. In this perspective, we highlight how proteomic studies have contributed to our understanding of autophagy in plants against the backdrop of yeast and animal studies. We then provide a framework for how the future application of proteomics in plant autophagy can uncover the mechanisms and outcomes of sculpting organelles during plant development, particularly through the identification of autophagy receptors and cargo in plants.
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关键词
proteomics, autophagy, protein degradation, organelle development
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