Population-based Meta-Analysis of Chloroquine: Informing Chloroquine Pharmacokinetics in COVID-19 Patients

40 patients underwent lumbosacral microdiscectomy in a 12 months period covering the years 1988-1989 in our center. For the purpose of the present study, we considered the 30 cases who underwent CT control of the operated interspaces and of the adjacent vertebral endplates. This was routinely carried out on the 3rd post-operative day. The present study failed to show correlations between early post-operative CT data and subsequent clinical results in this unselected series of patients. In fact an image suggesting persistent disc herniation was as a rule observed in spite of satisfactory clinical results, and other CT findings that have been considered of clinical significance, such as intraspinal air and low attenuation of disc space, were commonly observed in patients with an uncomplicated post-operative course. The present study suggests that early post-operative CT appears to be of no value in the management of potential early complications of low-back surgery. The introduction of MRI appears to offer other possibilities in the evaluation and management of failed back surgery syndrome (FBSS).