Precondition Your Donor Pig For Your Successful Allograft!

Kidney transplantation has become a lifesaver for patients worldwide. The major organ sources are brain dead donors (BDD). Accumulating evidence suggests that brain death contributes to an impairment of renal function and to nephron loss by acute tubular necrosis (ATN). Together with the surgical procedure, this inevitably results in acute kidney injury (AKI). Devising appropriate models to study brain death-induced AKI and associated delayed graft function (DGF) is technically challenging.