Protective Role of LRP1 in Second Heart Field-derived Smooth Muscle Cells Against Angiotensin II-induced Thoracic Aortic Aneurysm

Hisashi Sawada,Hideyuki Higashi,Debra L. Rateri,Deborah A. Howatt,Jessica J. Moorleghen, Bradley C. Wright,Lang H. Lee,Sasha A. Singh,Masanori Aikawa,Mark W. Majesky,Alan Daugherty

Arteriosclerosis, Thrombosis, and Vascular Biology（2019）

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摘要

Objective: Thoracic aortic aneurysms (TAAs) display a gradient of pathology across the media that is most pronounced in the outer elastin layers of the ascending aorta. The smooth muscle cells (SMC...

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