Cytological Diagnosis Of Patients With Extramammary Paget'S Disease Of The Vagina

Extramammary Paget's Disease (EMPD), also called extramammary eczematoid carcinoma, is classified as primary and secondary EMPD based on the pathogenic mechanism. The origin of the Paget cells of primary EMPD is still controversial. Apocrine or eccrine gland cells, such as Bartholin's gland, and intraepidermal pluripotent keratinocyte stem cells have been considered possible originating cells of primary EMPD. Secondary EMPD usually originates from the malignancies of rectum, cervix, and urinary bladder. We report a case of a 58-year-old woman suffering from intermittent vaginal bleeding for half a year, who was diagnosed as EMPD by vaginal cytology.