PRS45 RISK FACTORS ASSOCIATED WITH REACTIONS TO PEANUT DUE TO ACCIDENTAL EXPOSURE RESULTING IN INPATIENT OR EMERGENCY DEPARTMENT VISITS

To identify risk factors associated with reactions to peanut following accidental exposure resulting in inpatient (IP) or emergency department (ED) visits. Individuals with peanut allergy (PA) were identified from a large US administrative claims database (1999–2017). Continuous health plan enrollment was split into 12-month study periods (patient-years). Report of a diagnosis code of PA or anaphylactic reaction due to peanut in medical claims in an IP/ED setting during a 12-month study period constituted events included in a logistic regression model. These events represent a subgroup of potential reactions to peanut experienced by these individuals with PA (does not include those managed outside an IP/ED setting). This model included factors such as demographic characteristics, comorbidity profile and healthcare resource utilization measured during the pre-12-month study period; odds ratios (OR) and 95% confidence intervals (CI) were reported. A total of 10,959 individuals with PA, representing 55,193 patient-years, were included in the analysis (at the patient-year level: 16% were aged 2-3years, 50% 4–11years, 17% 12–17years, 6% 18-30years, and 10% ≥31years; 42% were female). A total of 1,243 reactions to peanut were observed in an IP/ED setting. Risk factors associated with increased odds of reacting to peanut included: age (adults, particularly young adults 18-30years [OR(95% CI)=3.19(2.66-3.83)]; adolescents 12-17years [OR(95% CI)=1.65(1.41-1.93)]; toddlers 2-3years [OR(95% CI)=1.68(1.42-1.98)]; reference 4-11years), reaction(s) to peanut observed during the previous year (OR[95% CI]=1.66[1.23-2.24]), asthma (OR[95% CI]=1.33[1.18-1.51]), and male gender (OR[95% CI]=1.14[1.01-1.28]) (all p<0.05). Practice of peanut avoidance is not sufficient to prevent reactions to peanut. Individuals with previous reaction(s) to peanut, asthma and males were observed to have a higher risk in this study focusing on reactions to peanut resulting in IP/ED visits. These factors should be considered in the management of PA and eventually in treatment decision making by healthcare professionals.