Manipulating the TCR signaling network for cellular immunotherapy: Challenges & opportunities
Molecular Immunology(2020)
摘要
•T cell receptor signaling plays a key role in T cell activation and differentiation processes.•Recent studies examine the effects of specific molecular networks downstream of T cell receptor signaling.•Targeting T cell receptor signaling may provide novel cancer immunotherapeutic approaches with decreased adverse side effects.
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关键词
T cell activation,Self-peptide,TCR signaling,T cell differentiation
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