Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail

James T. Nguyen,Dan-Dan Tian,Rakshit S. Tanna,Deena L. Hadi,Sumit Bansal,Justina C. Calamia,Christopher M. Arian,Laura M. Shireman,Balint Molnar,Miklos Horvath,Joshua J. Kellogg,Matthew E. Layton,John R. White,Nadja B. Cech,Richard D. Boyce,Jashvant D. Unadkat,Kenneth E. Thummel,Mary F. Paine

CLINICAL PHARMACOLOGY & THERAPEUTICS（2021）

Cited 16|Views55

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Key words

breast cancer resistance protein (BCRP),drug interaction,goldenseal,in vitro-in vivo extrapolation,metformin,multidrug and toxin extrusion protein (MATE),natural product,organic anion transporter (OAT),organic anion transporting polypeptide (OATP),organic cation transporter (OCT),probe cocktail,transporters

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