Prevalence, Self-Awareness, And Ldl Cholesterol Levels Among Patients Highly Suspected As Familial Hypercholesterolemia In A Japanese Community

Backgrounds: The prevalence of familial hypercholesterolemia (FH) among Japanese populations is still unclear. In addition, no prior data exist regarding the self-awareness. Accordingly, we aimed to investigate the prevalence, self-awareness, and LDL-C of patients with highly suspected as FH using data obtained in a community-based medical checkups.Methods: This study included 52,276 subjects (18,588 men, 35.6%) aged >= 40 years who underwent the Japanese specific health checkup in Kanazawa City during 2018. We assessed the self-awareness of dyslipidemia (and the age) as well as the prevalence of patients with highly suspected as FH whose naive LDL-C levels were >= 250 mg/dl. Naive LDL-C levels were estimated by the adjustment (LDL-C/0.7) for those on lipid-lowering medication. We divided subjects into 3 groups based on their naive LDL cholesterol level (>= 250 mg/dl, 140-249, and <= 139 mg/dl).Results: We identified 262 (0.5%) individuals highly suspected as FH whose naive LDL-C levels were >= 250 mg/dl. Most of them (234 among 262, 89%) were under lipid-lowering medication; however, the self-awareness as dyslipidemia was not quite high (200 among 262, 76%), and their mean LDL-C level under lipid-lowering medication was 203 +/- 35 mg/dl. Interestingly, the age of acknowledgement of dyslipidemia among the patients with highly suspected as FH was significantly younger than those in other categories (58 vs. 60/62 yrs, respectively, p < 0.05 for both).Conclusions: The prevalence of patients highly suspected as FH was around 1 in 200, and their self-awareness as well as control were not still good enough among Japanese general populations.