Household Paired Design Reduces Variance and Increases Power in Multi-City Gut Microbiome Study in Multiple Sclerosis
Xiaoyuan Zhou,Sneha Singh,Ryan Baumann,Patrick Barba, James Landefeld,Patrizia Casaccia,Ilana Katz Sand,Zongqi Xia,Howard Weiner,Tanuja Chitnis,Siddharthan Chandran,Peter Connick,David Otaegui,Tamara Castillo-Trivino,Stacy J. Caillier,Adam Santaniello,Gail Ackermann,Greg Humphrey,Laura Negrotto,Mauricio Farez,Reinhard Hohlfeld,Anne-Katrin Probstel,Xiaoming Jia,Jennifer Graves,Amit Bar-or,Jorge R. Oksenberg, Jeffery Gelfand,Michael R. Wilson,Elizabeth Crabtree,Scott S. Zamvil,Jorge Correale,Bruce A. C. Cree,Stephen L. Hauser,Rob Knight,Sergio E. Baranzini MULTIPLE SCLEROSIS JOURNAL（2021）
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Multiple sclerosis,gut microbiome,16S rRNA sequencing,shallow whole-metagenome sequencing,diet
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