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    • Rituximab Preferentially Eliminates BCR Signaling Proficient Chronic Lymphocytic Leukemia B Cells in Vivo

    Gabriela Pavlasova,Marek Borsky,Katerina Musilova,Vaclav Seda,Katerina Cerna,Jitka Osickova,Eva Vojackova,Yvona Brychtova,Michael Doubek,Sarka Pospisilova,Jiri Mayer,Marek Mraz

    Blood（2016）SCI 1区

    CEITEC MU | Univ Hosp Brno

    Cited 0|Views53
    Abstract
    The use of anti-CD20 antibody rituximab has significantly improved the outcome of patients with chronic lymphocytic leukemia (CLL). Rituximab has been shown to act through several mechanisms including antibody-dependent cell cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), direct induction of apoptosis, and sensitization to chemotherapy. However, the exact contribution of each of these mechanisms to the clinical efficacy of rituximab in vivo and the exact mechanism of its action remain unclear. Importantly, the levels of cell surface CD20 expression were shown to associate with the efficacy of rituximab.
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