A unique small molecule pair controls the plant circadian clock

Takahiro N Uehara,Saori Takao,Hiromi Matsuo,Ami N. Saito,Eisuke Ota,Azusa Ono, Kenichiro Itami,Toshinori Kinoshita,Junichiro Yamaguchi,Norihito Nakamichi

biorxiv（2020）

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摘要

Our study provides a unique small molecule pair that regulates the pace of the clock in opposite ways, likely by targeting unknown factors. Small differences at the atomic level can reverse the period tuning activities. and are essential for the activity of in period shortening.

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关键词

<italic>Arabidopsis thaliana</italic>,circadian clock,high-throughput chemical screening,small molecules,structure-activity relationship (SAR)

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