Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum

Silvia Haase,Melanie Condron, David Miller,Dounia Cherkaoui,Sarah Jordan,Jacqueline M Gulbis,Jake Baum

Molecular and Biochemical Parasitology（2021）

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摘要

•Identification of a phospholipid scramblase in P. falciparum (PfPLSCR).•PfPLSCR is conserved across the genus and in closely related unicellular algae.•Recombinant PfPLSCR shows metal-ion dependent phospholipid translocase activity.•PfPLSCR is expressed in asexual stages and membrane associated.•PfPLSCR is shown to be non-essential for asexual parasite development.

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关键词

Malaria,Plasmodium falciparum,Invasion,Phospholipid scramblase,Liposomes,Gametocytes

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