A phosphoproteomic approach reveals that PKD3 controls phenylalanine and tyrosine metabolism

Alexander E. Mayer,Angel Loza-Valdes,Werner Schmitz,Jonathan Trujillo Viera,Michael Leitges,Andreas Schlosser,Grzegorz Sumara

biorxiv（2020）

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摘要

Taken together, our comprehensive proteomic approach established that PKD3 determine the rate of phenylalanine to tyrosine conversion in the liver. Therefore, our data indicate that PKD3 might play a role in development of diseases related to the defective tyrosine and phenylalanine metabolism.

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关键词

Protein Kinase D3 (PKD3),phenylalanine hydroxylase (PAH),phenylalanine (Phe),tyrosine (Tyr),Phenylketonuria (PKU),Hepatocytes,Glucagon

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