Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium Falciparum

Xin Jiang,Yafei Yuan,Jian Huang,Shuo Zhang,Shuchen Luo,Nan Wang,Debing Pu,Na Zhao,Qingxuan Tang,Kunio Hirata,Xikang Yang,Yaqing Jiao,Tomoyo Sakata-Kato,Jia-Wei Wu,Chuangye Yan,Nobutaka Kato, Hang Yin,Nieng Yan

Cell（2020）

引用 48|浏览97

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关键词

malaria parasite,Plasmodium falciparum,antimalarial,structure-facilitated drug discovery,glucose transporter,hexose transporter,PfHT1,crystal structure,inhibitor-binding-induced pocket,orthosteric and allosteric dual inhibition

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