A Closed-loop Audit of 5 versus 10 Days of Primary GCSF Prophylaxis to Reduce the Incidence of Febrile Neutropenia in Early Breast Cancer Treatment
Clinical Oncology(2019)
摘要
Purpose: Current guidelines recommend that patients with early breast cancer receiving chemotherapy that confers >20% risk of febrile neutropenia should have primary prophylactic granulocyte colony-stimulating factor (GCSF) on days 2–6 of chemotherapy [1,2]. An initial audit [3] demonstrated non-inferiority of 5 days versus 10 days of primary prophylactic GCSF in respect of febrile neutropenia rates seen in early breast cancer chemotherapy. Since 1 August 2016, our centre has switched from 10 days of prophylactic GCSF to 5 days. We re-audited febrile neutropenia rates following our change in practice.
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关键词
febrile neutropenia,primary gcsf prophylaxis,early breast cancer treatment,breast cancer,closed-loop
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