Diet-induced Obese Mouse Hearts Tolerate an Acute High-Fatty Acid Exposure That Also Increases Ischemic Tolerance.
American journal of physiology Heart and circulatory physiology(2020)
Abstract
An acute myocardial fat-load leads to oxidative stress, oxygen wasting, mechanical inefficiency, hyperacetylation, and impaired mitochondrial function, which can contribute to reduced ischemic tolerance. Following obesity/insulin resistance, hearts were less affected by a high fat-load, which subsequently also improved ischemic tolerance. This study highlights that an acute fat-load affects normal and obese hearts differently and that obesity renders hearts less vulnerable to the disadvantageous effects of an acute fat-load.
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Key words
acetylation,cardiac efficiency,heart perfusion,mitochondrial respiration,oxygen consumption,pressure volume
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