Acetylase inhibitor SI-2 is a potent anti-inflammatory agent by inhibiting NLRP3 inflammasome activation

Liping Liu,Xueming Xu,Ningjie Zhang,Yening Zhang,Kai Zhao

International Immunopharmacology（2020）

Cited 9|Views18
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Abstract
•SI-2 specifically inhibits NLRP3 inflammasome activation in vitro and in vivo.•SI-2 inhibits NLRP3 inflammasome activation in THP-1 cells.•SI-2 blocks the ASC speck formation by interrupting the interaction between NLRP3 and ASC.
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Key words
SI-2,NLRP3 inflammasome,ASC speck
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