The relationship between HNF 1 A variations and type 2 diabetes mellitus risk factors in the Uyghur population in Urumqi

Type 2 diabetes (T2DM) is a main threaten health problem in Uyghur minority population in China. This study investigated the relationship between the common variations of hepatocyte nuclear factor 1A (HNF1A) of rs2464196, rs1169288, and rs1169289, and T2DM in a Uyghur population. A case-control study was conducted on 202 Uyghur subjects, and the relationship between HNF1A variants and the risk of T2DM was assessed. For rs2464196, subjects with AG genotype who smoked or had a high LDL-C level had an increased risk of T2DM (OR=2.284, 95% CI=1.034-5.046 and OR=4.157, 95% CI=1.539-11.225, respectively). In conjunction with the GG genotype of this variant, higher triglycerides (TG), high-density lipoprotein (HDL-C), and lower low-density lipoprotein (LDL-C) were associated with increased risk of T2DM (OR=2.908, 3.058 and 5.619). For rs1169288, TG genotype with higher TC, TG, LDL-C and lower HDL-C was associated with increased risk for T2DM (OR=2.793, OR=4.076, OR=5.043 and OR=4.649, respectively). Meanwhile, those with GG genotype and higher TG, LDL-C, and lower HDLC got increased risk for T2DM (OR=2.461, OR=3.042 and OR=3.638). For rs1169289, smoking or a high LDL-C in conjunction with the CG genotype was associated with increased risk for T2DM (OR=5.370 and OR=4.575), while higher TC, TG, LDL-C, and lower HDL-C with GG genotype was associated with increased risk of T2DM (OR=2.25, OR=2.17, OR=2.999, and OR=4.217). The HNF1A variants of rs2464196, rs1169288 and rs1169289 may interact with persistent smoking and/or blood lipids to influence the risk of T2DM in the Uyghur population in Urumqi.