Regulation of genomic stability and senescence by the AMPK-related kinase ARK 5

Thank you for submitting your manuscript for consideration by The EMBO Journal. It has now been seen by three expert reviewers, whose comments are copied below. As you will see, they all find the link of ARK5 and LATS1 to replicative senescence you identified potentially interesting and therefore in principle worth of reporting in The EMBO Journal. All of them nevertheless also bring up a number of substantive (and partially recurring) issues that would need to be satisfactorily addressed or clarified before publication may be warranted.