Design and Synthesis of Indolyl Chalcone Analogues and Evaluation of Their Osteogenic Activity

We have designed and synthesized a series of novel functionalized indolyl chalcones and flavone conjugates via Claisen-Schmidt reaction. All the synthesized compounds were evaluated for their osteogenic activity. Among the synthesized compounds, four compounds showed significantly increased ALP activity whereas the novel compound 3b has shown significant bone matrix mineralization and mRNA expressions of osteogenic marker genes, BMP2, RUNX-2 and OCN at 1 pM concentration.