Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma

Renal cell carcinoma (RCC) is the most common malignant tumour of adult kidney (Eble et al., 2004), and RCC’s histopathology is subdivided into various categories, which clear cell renal cell carcinoma (ccRCC) is the most common pathological category, accounting for 70-80% of all RCCs (Young et al., 2001; Matsuura et al., 2011). In the last decades, there have been immense improvements in the treatment of ccRCC, but approximately 30% of the patients would develop to metastatic after surgical therapy (Janzen et al., 2003; Cohen et al., 2005; Chen et al., 2011). Although some environmental and genetic factors have been found to