Stem Cell Factor Attenuates Formation of Acetaminophen– Glutathione Conjugate in Kidney of Mice Treated With a Toxic Dose of Acetaminophen

In this study the possible effects of stem cell factor treatment on acetaminophen renal toxicity via conjugate formation with cellular glutathione was investigated. Mice treated with Stem cell factor (40μg/kg B.W i.p) 30 min following acetaminophen (300 mg/kg B.W i.p.) and sacrificed at intervals of 6, 12 and 24 h. The levels of acetaminophenglutathione conjugate in kidney tissues showed that stem cell factor treatment given 30 min after acetaminophen injection to mice caused a significant decrease acetaminophen-glutathione conjugate formation in 6 and 12 h. Under these circumstances, serum urea and creatinin level reduced (p < 0.05) in mice treated with stem cell factor compared to mice treated with acetaminophen alone. These data show that treatment with stem cell factor reduced acetaminophenrelated toxicity. The part played by stem cell factor is probably by inhibition of acetaminophen-glutathione formation and retaining of cellular glutathione.