The Expression Of B7-H4 In Serum And Lymphoma Tissues And Its Clinical Significance

Objective: To investigate the expression of B7-H4 in serum and lymphoma tissues of patients and its clinical significance. Methods: Ninety-eight lymphoma patients, who were treated in our hospital from January 2014 to December 2016, were recruited and divided into the early-onset group (76 cases; 12 cases with Hodgkin's lymphoma (HL), 64 cases with Non-Hodgkin's lymphoma) and the recurrence group (22 cases). Additionally, the healthy controls consisted of 60 healthy volunteers. Meanwhile, 50 cases of lymphoma tissue specimens with complete information were collected and the controls were 39 cases of reactive lymphoid hyperplasia. The expression levels of B7-H4 in serum and lymphoma tissue were detected by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Results: The expression level of B7-H4 in serum of lymphoma patients was significantly higher than that of healthy controls (P<0.01), however, in which the difference was insignificant between the patients with Non-Hodgkin's lymphoma and patients with Hodgkin's lymphoma (P>0.05). In addition, the expression level of B7-H4 in early on set group was evidently lower than that of recurrence group (P<0.05). The B7-H4 positive rate in lymphoma tissues was drastically higher than that in reactive lymphoid hyperplasia with significant difference (P<0.05), while it showed an opposite result between Hodgkin's lymphoma tissues and Non-Hodgkin's lymphoma tissues (P>0.05). Conclusion: B7-H4 was high-expressed in serum and lymphoma tissues. And B7-H4 which is associated with the development and progression of lymphoma, has certain clinical significance for auxiliary diagnosis of lymphoma.