Cancer-specific production of N-acetylaspartate via NAT 8 L overexpression in non-small cell lung cancer and its potential as a circulating biomarker Running Title : Cancer-specific production of N-acetylaspartate in NSCLC

Departments of Molecular and Cell Biology, Bioengineering and Chemistry, Center for Systems Biology, University of Texas at Dallas, Richardson, TX 75080, USA; Hamon Center for Therapeutic Oncology Research, Department of Cell Biology, Children’s Medical Center Research Institute, Department of Pathology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Seoul, Korea.