Retroviral transfer of the human multidrug resistance-1 gene in human mobilized peripheral blood progenitor cells engrafting in NOD / SCID mice can confer chemoprotection

S. Laufs, B. Schiedlmeier,E. C. Buss,A. J. Schilz, K. Kühlcke, C. Baum,H. G. Eckert, S. Fruehauf,W. J. Zeller

semanticscholar（2002）

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摘要

Close cooperation exists with Priv.-Doz. Dr. S. Fruehauf and Prof. Dr. A.D. Ho of the Department of Internal Medicine V of the University of Heidelberg; the aim of this cooperation is an optimization of high-dose chemotherapy with blood stem cell support using preclinical models (stem cell expansion, cytostatic drug resistance gene transfer) and experimental therapy of chronic myelogenous leukemia.

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