Changes in the application of therapeutic hypothermia in newborns with hypoxic-ischemic encephalopathy : a retrospective analysis

Inter-hospital transfer of preterm infants is associated with worse neurological outcomes. Chronic whole-body vibration (WBV) causes neurovascular injury, but it is unknown what impact a single, acute WBV exposure has on the developing brain as a potential mechanism of neuronal injury. Using our new rodent model of a single acute WBV exposure, as experienced during neonatal ambulance transfer, we have previously demonstrated outer cortical neuronal injury. We now hypothesise that the preterm phase of neuronal development is more susceptible to WBV induced traumatic brain injury (TBI) and aimed to explore neuronal injury in the whole developing brain.