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The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance

Jianxuan Zou,Richard J. Jones, Hua Wang,Isere Kuiatse,Fazal Shirazi,Elisabet E. Manasanch,Hans C. Lee,Robert Sullivan,Leah Fung,Normand Richard,Paul Erdman,Eduardo Torres,David Hecht,Imelda Lam,Brooke McElwee,Aparajita H. Chourasia,Kyle W. H. Chan,Frank Mercurio,David I. Stirling,Robert Z. Orlowski

JOURNAL OF MOLECULAR MEDICINE-JMM（2020）

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关键词
Multiple myeloma,Protein homeostatic modulator,Cereblon,Ikaros,Aiolos,GSPT1
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