High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms

Christiana Franke,Caroline Ferse, Jakob Kreye,S. Momsen Reincke,Elisa Sanchez-Sendin, Andrea Rocco,Mirja Steinbrenner, Stefan Angermair,Sascha Treskatsch,Daniel Zickler,Kai-Uwe Eckardt, Rick Dersch,Jonas Hosp, Heinrich J. Audebert,Matthias Endres, J. Christoph Ploner,Harald Prüß

Brain, Behavior, and Immunity（2021）

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摘要

•COVID-19 patients show a broad spectrum of neurological manifestations.•SARS-CoV-2 is scarcely detected in cerebrospinal fluid.•Viral-triggered autoimmune responses may lead to neurological symptoms.•Immunotherapy should be considered in CSF autoantibody-positive Covid-19 patients.

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关键词

COVID-19,CSF,Autoantibody,Neurology,Encephalitis,Autoimmunity,Viral-triggered

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